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• Activity deltas table
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Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 1.698

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr12_+_102859354	3.162		HSP90B1	heat shock protein 90kDa beta (Grp94), member 1
chr4_+_100714995	3.100		MTTP	microsomal triglyceride transfer protein
chr8_+_39890484	2.778	NM_002164	IDO1	indoleamine 2,3-dioxygenase 1
chr1_-_181889070	2.343	NM_203454	APOBEC4	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)
chr7_+_129057152	2.093	NM_001040110	NRF1	nuclear respiratory factor 1
chr14_-_106241445	2.045		IGHV4-31 IGHV1-69 IGHA1 IGHG1 IGHG3 IGHM	immunoglobulin heavy variable 4-31 immunoglobulin heavy variable 1-69 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker) immunoglobulin heavy constant mu
chr1_+_165565006	2.043		POU2F1	POU class 2 homeobox 1
chr1_+_165564904	2.012	NM_001198783	POU2F1	POU class 2 homeobox 1
chr14_-_106240998	2.010		IGHV1-69 IGHG1	immunoglobulin heavy variable 1-69 immunoglobulin heavy constant gamma 1 (G1m marker)
chr1_-_24112345	1.981	NM_001841	CNR2	cannabinoid receptor 2 (macrophage)
chr6_-_108252200	1.930	NM_198081	SCML4	sex comb on midleg-like 4 (Drosophila)
chr12_-_66839589	1.712	NM_000619	IFNG	interferon, gamma
chr16_-_54424517	1.712	NM_001025194 NM_001025195 NM_001266	CES1	carboxylesterase 1
chr21_+_39117064	1.692		ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr7_+_37689903	1.634
chr7_+_29486010	1.563	NM_001039936	CHN2	chimerin (chimaerin) 2
chrX_+_7147471	1.551	NM_000351	STS	steroid sulfatase (microsomal), isozyme S
chrX_+_65152004	1.518
chr4_+_114433551	1.467		ANK2	ankyrin 2, neuronal
chr6_+_167445284	1.445	NM_004367	CCR6	chemokine (C-C motif) receptor 6
chr15_-_76313896	1.431	NM_015162	ACSBG1	acyl-CoA synthetase bubblegum family member 1
chr14_-_105804211	1.394		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_122794859	1.293	NM_016298	FBXO40	F-box protein 40
chr4_-_74307637	1.266		ANKRD17	ankyrin repeat domain 17
chr12_-_121767272	1.237	NM_006018	GPR109B	G protein-coupled receptor 109B
chr1_+_168381811	1.207	NM_001136107	METTL11B	methyltransferase like 11B
chr7_+_80105858	1.207		CD36	CD36 molecule (thrombospondin receptor)
chr14_-_106154332	1.204		LOC100126583 IGHG1	hypothetical LOC100126583 immunoglobulin heavy constant gamma 1 (G1m marker)
chr10_+_91488704	1.139		KIF20B	kinesin family member 20B
chr14_-_105610144	1.113		IGHA1 IGHG1 IGHG3	immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant gamma 1 (G1m marker) immunoglobulin heavy constant gamma 3 (G3m marker)
chr6_+_32515596	1.100	NM_019111	HLA-DRA	major histocompatibility complex, class II, DR alpha
chr7_+_80105907	1.086		CD36	CD36 molecule (thrombospondin receptor)
chr21_+_41663853	1.060		MX2	myxovirus (influenza virus) resistance 2 (mouse)
chr3_-_152585226	0.985	NM_022788	P2RY12	purinergic receptor P2Y, G-protein coupled, 12
chr9_-_21340885	0.980	NM_021002	IFNA6	interferon, alpha 6
chr3_+_45902999	0.977	NM_006641 NM_031200	CCR9	chemokine (C-C motif) receptor 9
chr6_-_32605898	0.972	NM_002125	HLA-DRB5	major histocompatibility complex, class II, DR beta 5
chr2_-_231697999	0.953	NM_000867	HTR2B	5-hydroxytryptamine (serotonin) receptor 2B
chr6_-_167491305	0.947	NM_005299	GPR31	G protein-coupled receptor 31
chr14_-_106330781	0.917		IGHV5-78	immunoglobulin heavy variable 5-78 pseudogene
chr10_-_69125932	0.910	NM_013266	CTNNA3	catenin (cadherin-associated protein), alpha 3
chr15_-_74941339	0.903	NM_001145923	SCAPER	S-phase cyclin A-associated protein in the ER
chr4_-_123761615	0.896	NM_021803	IL21	interleukin 21
chr17_-_64649608	0.887	NM_080284	ABCA6	ATP-binding cassette, sub-family A (ABC1), member 6
chr16_+_82540172	0.871	NM_013370 NM_182980	OSGIN1	oxidative stress induced growth inhibitor 1
chr11_-_16380967	0.871	NM_001145819 NM_017508	SOX6	SRY (sex determining region Y)-box 6
chr14_-_105524207	0.866		IGHG1	immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_3324096	0.864	NM_001128085	ASPA	aspartoacylase
chr9_+_134843918	0.851	NM_001135031 NM_004188	GFI1B	growth factor independent 1B transcription repressor
chr8_-_82557956	0.847	NM_001442	FABP4	fatty acid binding protein 4, adipocyte
chr12_-_8656705	0.840	NM_020661	AICDA	activation-induced cytidine deaminase
chr9_-_21132143	0.834	NM_002177	IFNW1	interferon, omega 1
chr1_+_246635918	0.829	NM_030904	OR2T1	olfactory receptor, family 2, subfamily T, member 1
chr1_-_93172119	0.824
chr7_+_80105718	0.823	NM_000072 NM_001001548	CD36	CD36 molecule (thrombospondin receptor)
chr6_-_31668476	0.821	NM_001145466 NM_001145467 NM_147130	NCR3	natural cytotoxicity triggering receptor 3
chr12_-_119733062	0.813		SPPL3	signal peptide peptidase 3
chrX_+_128741562	0.802	NM_018990	SASH3	SAM and SH3 domain containing 3
chrX_+_128741578	0.800		SASH3	SAM and SH3 domain containing 3
chr4_-_149577404	0.797
chr2_+_128644510	0.791		UGGT1	UDP-glucose glycoprotein glucosyltransferase 1
chr16_+_28850760	0.786	NM_001178098 NM_001770	CD19	CD19 molecule
chr2_+_113601616	0.769		IL1RN	interleukin 1 receptor antagonist
chr17_-_76720342	0.755		AATK	apoptosis-associated tyrosine kinase
chr12_-_121753795	0.747	NM_177551	GPR109A	G protein-coupled receptor 109A
chr3_-_153541468	0.737	NM_001123228	TMEM14E	transmembrane protein 14E
chr11_+_123945102	0.730	NM_001005194	OR8A1	olfactory receptor, family 8, subfamily A, member 1
chr7_-_36730525	0.711	NM_001177506 NM_001177507 NM_001637	AOAH	acyloxyacyl hydrolase (neutrophil)
chr10_+_114123765	0.711		ACSL5	acyl-CoA synthetase long-chain family member 5
chr6_+_88021644	0.701		ZNF292	zinc finger protein 292
chr14_-_105712630	0.695		IGHV4-31 IGHA1 IGHA2 IGHG1	immunoglobulin heavy variable 4-31 immunoglobulin heavy constant alpha 1 immunoglobulin heavy constant alpha 2 (A2m marker) immunoglobulin heavy constant gamma 1 (G1m marker)
chr3_+_123256902	0.694	NM_175862	CD86	CD86 molecule
chr16_-_45339605	0.687	NM_182493	MYLK3	myosin light chain kinase 3
chr18_-_3001944	0.676	NM_014646	LPIN2	lipin 2
chr2_-_127817143	0.675	NM_006609	MAP3K2	mitogen-activated protein kinase kinase kinase 2
chr17_+_12564330	0.659	NM_001146313	MYOCD	myocardin
chr12_+_25096472	0.657	NM_006152	LRMP	lymphoid-restricted membrane protein
chr11_+_69165018	0.657	NM_053056	CCND1	cyclin D1
chr1_+_246682699	0.653	NM_001004136	OR2T2	olfactory receptor, family 2, subfamily T, member 2
chr2_+_113601608	0.650	NM_173842	IL1RN	interleukin 1 receptor antagonist
chr8_+_120148604	0.645	NM_006438	COLEC10	collectin sub-family member 10 (C-type lectin)
chr2_+_169367345	0.620	NM_001039724 NM_001171632 NM_052946	NOSTRIN	nitric oxide synthase trafficker
chr7_+_89681069	0.614	NM_001040666	STEAP2	six transmembrane epithelial antigen of the prostate 2
chr6_+_64414389	0.611	NM_015153	PHF3	PHD finger protein 3
chr10_+_114123828	0.606	NM_203379	ACSL5	acyl-CoA synthetase long-chain family member 5
chr11_+_69165159	0.595		CCND1	cyclin D1
chr2_-_20390601	0.594	NM_015317	PUM2	pumilio homolog 2 (Drosophila)
chr19_-_5789740	0.594		FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr2_-_37397669	0.594	NM_005813	PRKD3	protein kinase D3
chr10_-_11614279	0.587	NM_001080491	USP6NL	USP6 N-terminal like
chr1_+_245835478	0.587	NM_001001914	OR2G3	olfactory receptor, family 2, subfamily G, member 3
chr2_+_68445821	0.586	NM_002664	PLEK	pleckstrin
chr10_+_5478521	0.585	NM_005863	NET1	neuroepithelial cell transforming 1
chr1_+_50347176	0.573	NM_001144774 NM_021952	ELAVL4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chrX_-_15312390	0.566	NM_004469	FIGF	c-fos induced growth factor (vascular endothelial growth factor D)
chr1_+_67404756	0.560	NM_144701	IL23R	interleukin 23 receptor
chr2_+_87536174	0.555		NCRNA00152	non-protein coding RNA 152
chr1_+_153222393	0.552	NM_001184891 NM_001184892 NM_025207 NM_201398	FLAD1	FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr20_+_18742369	0.549	NM_178483	C20orf79	chromosome 20 open reading frame 79
chr11_+_69165119	0.548		CCND1	cyclin D1
chr14_-_106119742	0.546		IGLJ3 IGHG1	immunoglobulin lambda joining 3 immunoglobulin heavy constant gamma 1 (G1m marker)
chr17_+_73511843	0.543	NM_001142640 NM_018996	TNRC6C	trinucleotide repeat containing 6C
chr13_-_27441290	0.542	NM_001265	CDX2	caudal type homeobox 2
chr3_-_42892195	0.542		CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1
chr9_-_85773899	0.539		HNRNPK	heterogeneous nuclear ribonucleoprotein K
chr12_-_103846186	0.535	NM_032148	SLC41A2	solute carrier family 41, member 2
chr11_+_69165065	0.531		CCND1	cyclin D1
chr19_+_7734034	0.525	NM_001144904 NM_001144905 NM_001144906 NM_001144907 NM_001144908 NM_001144909 NM_001144910 NM_001144911 NM_014257	CLEC4M	C-type lectin domain family 4, member M
chr2_+_190248955	0.523	NM_144708	ANKAR	ankyrin and armadillo repeat containing
chr15_+_20287609	0.516	NM_001001413	GOLGA6L1	golgin A6 family-like 1
chr1_-_158948176	0.516	NM_001778	CD48	CD48 molecule
chr19_+_6838576	0.510	NM_001974	EMR1	egf-like module containing, mucin-like, hormone receptor-like 1
chr18_-_3835295	0.505	NM_001003809	DLGAP1	discs, large (Drosophila) homolog-associated protein 1
chr10_+_77212524	0.502	NM_032024	C10orf11	chromosome 10 open reading frame 11
chr2_-_238813284	0.498		HES6	hairy and enhancer of split 6 (Drosophila)
chr2_+_102401580	0.495	NM_003853	IL18RAP	interleukin 18 receptor accessory protein
chr1_-_180908639	0.495	NM_001102450 NM_033345	RGS8	regulator of G-protein signaling 8
chr14_+_22859236	0.490	NM_004643	PABPN1	poly(A) binding protein, nuclear 1
chr2_-_238813365	0.489	NM_001142853 NM_018645	HES6	hairy and enhancer of split 6 (Drosophila)
chr1_+_153222464	0.489		FLAD1	FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae)
chr14_-_106149623	0.489
chr14_+_59934178	0.488
chr15_+_78520634	0.485		ARNT2	aryl-hydrocarbon receptor nuclear translocator 2
chr4_-_21155376	0.480	NM_001035004	KCNIP4	Kv channel interacting protein 4
chr11_+_59902530	0.479	NM_021201 NM_206938 NM_206939 NM_206940	MS4A7	membrane-spanning 4-domains, subfamily A, member 7
chr1_+_149877955	0.473		SNX27	sorting nexin family member 27
chr5_+_27508139	0.472		LOC643401	hypothetical protein LOC643401
chr9_-_99740243	0.471	NM_197978	HEMGN	hemogen
chr2_+_191009265	0.469		MFSD6	major facilitator superfamily domain containing 6
chr16_+_83349816	0.466		USP10	ubiquitin specific peptidase 10
chr2_-_215605054	0.466	NM_015657	ABCA12	ATP-binding cassette, sub-family A (ABC1), member 12
chr13_-_22905822	0.463	NM_014363	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)
chr6_-_22410993	0.461	NM_001163558	PRL	prolactin
chr2_+_233443237	0.458	NM_206895	C2orf82	chromosome 2 open reading frame 82
chr11_+_59804634	0.457	NM_148975	MS4A4A	membrane-spanning 4-domains, subfamily A, member 4
chr13_-_27441143	0.449		CDX2	caudal type homeobox 2
chr18_+_59726183	0.444		SERPINB10	serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr1_-_232681471	0.435	NM_005646	TARBP1	TAR (HIV-1) RNA binding protein 1
chr14_+_38720085	0.435		PNN	pinin, desmosome associated protein
chr17_+_63367052	0.433		BPTF	bromodomain PHD finger transcription factor
chrX_-_55037235	0.433	NM_002625	PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr7_+_90176647	0.432	NM_012395	CDK14	cyclin-dependent kinase 14
chr4_-_110942783	0.431	NM_000204	CFI	complement factor I
chr6_+_64344307	0.426		PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr6_+_6533932	0.422	NM_004271	LY86	lymphocyte antigen 86
chr10_+_114033403	0.421	NM_058222	TECTB	tectorin beta
chr4_+_17125885	0.421	NM_001079827	CLRN2	clarin 2
chr11_+_59027624	0.420	NM_001004706	OR4D11	olfactory receptor, family 4, subfamily D, member 11
chr1_+_57093030	0.418	NM_000562	C8A	complement component 8, alpha polypeptide
chr1_-_155936904	0.416	NM_052939	FCRL3	Fc receptor-like 3
chr5_-_43448174	0.416	NM_148672	CCL28	chemokine (C-C motif) ligand 28
chr6_+_131190237	0.414	NM_001195597	LOC285733	hypothetical LOC285733
chr8_-_93177057	0.412	NM_001198625 NM_001198626 NM_001198627 NM_001198631 NM_001198634 NM_001198679	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr13_-_27441423	0.411		CDX2	caudal type homeobox 2
chr14_-_93512818	0.409		ASB2	ankyrin repeat and SOCS box containing 2
chr3_+_109504021	0.397	NM_007072	HHLA2	HERV-H LTR-associating 2
chr2_+_46560207	0.397	NM_001145051	LOC388946	transmembrane protein ENSP00000343375
chr3_+_16949585	0.396	NM_015184	PLCL2	phospholipase C-like 2
chr14_-_34414603	0.390	NM_013448 NM_182648	BAZ1A	bromodomain adjacent to zinc finger domain, 1A
chr1_-_180627934	0.388	NM_001033044 NM_002065	GLUL	glutamate-ammonia ligase
chrX_+_71280758	0.387	NM_207422	FLJ44635	TPT1-like protein
chr6_+_26264531	0.386		HIST1H1E	histone cluster 1, H1e
chr12_-_14982708	0.385	NM_152321	ERP27	endoplasmic reticulum protein 27
chr6_-_43384507	0.385	NM_206922	CRIP3	cysteine-rich protein 3
chr9_+_2707525	0.384	NM_133497	KCNV2	potassium channel, subfamily V, member 2
chr6_-_116553918	0.377	NM_000493	COL10A1	collagen, type X, alpha 1
chr5_+_176449156	0.373	NM_022963	FGFR4	fibroblast growth factor receptor 4
chr3_+_32968069	0.373	NM_005508	CCR4	chemokine (C-C motif) receptor 4
chr13_+_50813168	0.372	NM_001101320	SERPINE3	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
chr17_+_24394043	0.371	NM_016518	PIPOX	pipecolic acid oxidase
chr3_-_150422474	0.371	NM_000096	CP	ceruloplasmin (ferroxidase)
chr1_-_246503738	0.368	NM_001004695	OR2T33	olfactory receptor, family 2, subfamily T, member 33
chr16_+_28993770	0.367		RRN3P2	RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr15_-_19007127	0.366	NM_001145004	GOLGA6L6	golgin A6 family-like 6
chr1_+_35317535	0.365	NM_024772	ZMYM1	zinc finger, MYM-type 1
chr9_-_21229975	0.363	NM_002172	IFNA14	interferon, alpha 14
chr15_+_63701322	0.362	NM_004727	SLC24A1	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr2_+_102345528	0.362	NM_003855	IL18R1	interleukin 18 receptor 1
chr11_-_35398077	0.360	NM_001195728	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chrX_+_101356905	0.359	NM_017809 NM_001099686	NXF2 NXF2B	nuclear RNA export factor 2 nuclear RNA export factor 2B
chr4_+_170817787	0.357		CLCN3	chloride channel 3
chr4_-_17415918	0.357		DCAF16	DDB1 and CUL4 associated factor 16
chr3_-_87408301	0.357	NM_000306 NM_001122757	POU1F1	POU class 1 homeobox 1
chr8_+_92184022	0.354	NM_001129890	LRRC69	leucine rich repeat containing 69
chr3_-_152478843	0.353	NM_014879	P2RY14	purinergic receptor P2Y, G-protein coupled, 14
chr9_-_21192201	0.351	NM_021057	IFNA7	interferon, alpha 7
chr8_+_1436938	0.351	NM_004745	DLGAP2	discs, large (Drosophila) homolog-associated protein 2
chr12_+_61645361	0.348		RPL14	ribosomal protein L14
chr13_+_96592051	0.347		MBNL2	muscleblind-like 2 (Drosophila)
chr2_+_68445936	0.347		PLEK	pleckstrin
chr12_-_101398288	0.346		IGF1	insulin-like growth factor 1 (somatomedin C)
chr5_+_140709907	0.345	NM_018922 NM_032095	PCDHGB1	protocadherin gamma subfamily B, 1
chr19_-_45141473	0.343		LOC440525 PRR13	proline rich 13 pseudogene proline rich 13
chr9_-_21197141	0.342	NM_002171	IFNA10	interferon, alpha 10
chr8_-_6783193	0.340	NM_001925	DEFA4	defensin, alpha 4, corticostatin
chr14_+_38772870	0.334	NM_054024	MIA2	melanoma inhibitory activity 2
chr11_-_104421240	0.333	NM_001017534 NM_052889	CARD16 CASP1	caspase recruitment domain family, member 16 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
chr20_-_31055892	0.332	NM_080675	SUN5	Sad1 and UNC84 domain containing 5
chr6_+_26291936	0.331	NM_003523	HIST1H2BE	histone cluster 1, H2be
chr2_-_6924092	0.329		CMPK2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
2.31	6.01e-07	GO:0006955	immune response
1.97	9.10e-07	GO:0002376	immune system process
1.31	1.15e-05	GO:0050896	response to stimulus
2.47	1.70e-04	GO:0050776	regulation of immune response
2.52	9.54e-04	GO:0045087	innate immune response
1.94	1.78e-03	GO:0006952	defense response
1.97	7.33e-03	GO:0002682	regulation of immune system process
2.57	8.64e-03	GO:0050778	positive regulation of immune response
2.17	1.25e-02	GO:0007606	sensory perception of chemical stimulus
2.23	1.54e-02	GO:0007608	sensory perception of smell
4.49	4.83e-02	GO:0072376	protein activation cascade

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.33	6.64e-04	GO:0005886	plasma membrane
1.32	8.09e-04	GO:0071944	cell periphery

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.71	4.59e-04	GO:0004888	transmembrane receptor activity
1.59	8.24e-04	GO:0004872	receptor activity
1.52	9.52e-04	GO:0004871	signal transducer activity
1.52	9.52e-04	GO:0060089	molecular transducer activity
2.27	3.34e-03	GO:0004984	olfactory receptor activity
1.80	5.15e-03	GO:0004930	G-protein coupled receptor activity